This study is designed to determine the response of adult stems cells, also referred to as mesenchymal stem cells (MSCs), to tissue injury resulting from thermal burns. The study will consist of a one time collection of a patient's blood, about one teaspoon, on the third day following the initial burn. MSCs in the blood will then be quantitated and identified using according to unique proteins found on their cell . Phase I/II trials suggest potential cardiovascular benefit from bone marrow–derived adult stem cells and umbilical cord blood–derived cells. 15 Striking results have been reported using adult stem cells to treat neurological conditions, including chronic stroke. 16 Positive long-term progression-free outcomes have been seen, including some remission, for multiple sclerosis, 17 as well as benefits in early trials for Cited by: 7.
Mar 25, · Related clinical research under way in China also uses adult stem cells, but they come directly from the patient, and no universal donor is used as in the Hopkins study. It remains unclear from earlier animal studies how or why the adult stem cells develop into new and healthy heart tissue, or exactly how long their healing effects last. Oklahoma Center for Adult Stem Cell Research NE 13th, MS #1 Oklahoma City, OK () ()Cell Email: [email protected]
This will allow us to turn large numbers of stem cells into retinal ganglion cells for cell replacement therapy. Second, we are just beginning to make progress in transplanting retinal ganglion cells into the retina in pre-clinical models, to study their integration into the adult retina, how they respond to light and grow back down the optic. The majority of clinical trials have focused on MSCs from bone marrow; however, stem cells from adult tissues may have limited paracrine and differentiation potential, which may be overcome by using UC-MSCs. Allogeneic UC-MSCs were assessed in the RIMECARD trial (Randomized Clinical Trial of Intravenous Infusion of Umbilical Cord Cited by: