Brainstem glioma is a serious condition that will be treated by a multidisciplinary team consisting of neurosurgeons, oncologists, and radiation oncologists. The primary goal of treatment is to prolong survival for patients, by slowing the growth of the tumor. For focal brainstem tumors which are low grade, cure and long-term survival are possible. Dec 02, · Patients will often be prescribed temozolomide at the same time as radiation therapy, either following surgery or as the first-line treatment. Brainstem Glioma Survival Rate in Adults. Brainstem gliomas occur more frequently in children than adults, representing less than 2 percent of gliomas in people over However, though they are rarer in adults, the tumors tend to be less Author: Dr. Paul Gigante.
Overview of Adult Brainstem Gliomas. Until , when Guillamo et al 10 first reported their series of 48 adult patients with brainstem gliomas, the majority of previous publications had dealt with pediatric patients alone, offering a good overview of the biology and treatment of this disease in children. Only few publications also included adult brainstem glioma cases in their analyses. 2, Perhaps the best line of evidence supporting the use of upfront chemotherapy (along with radiation) for adult brainstem glioma comes from the MD Anderson retrospective analysis, which demonstrated a striking difference in survival in adults with brainstem glioblastoma treated with the standard Stupp regimen (concurrent radiation and temozolomide followed by adjuvant temozolomide) vs. those who were not – median OS for patients treated with the Stupp Cited by:
Also, most cranial nerves (described below) start in the brain stem. The brain stem is divided into 3 main parts: the midbrain, pons, and medulla oblongata. Because the brain stem is a small area that is so essential for life, it might not be possible to surgically remove tumors in this area. Diffuse brainstem glioma is a rare disease in adults. Radiotherapy (RT) is usually considered to be the standard treatment. However, the role of chemotherapy in treating relapses after RT is unclear, and this study aimed to assess the use of temozolomide (TMZ) in this situation.